MSK-ACCESS V1
Things to know for MSK-ACCESS V1 for Research
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Things to know for MSK-ACCESS V1 for Research
Last updated
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It is a hybrid capture panel designed for Analysis of Circulating cfDNA to Evaluate Somatic Status using the Unique Molecular Index (UMIs) for high sensitivity. MSK-ACCESS is 13% as large, captures 47% of all mutations detected by MSK-IMPACT.
Selected exons of 129 genes for mutation detection
OncoKB Level 1-4
High rates of mutations
SNPs of zygosity & copy number of 12 genes
Common SNPs for genome-wide copy number
Introns for structural variants of 10 genes
Clonal hematopoiesis genes
Matched cfDNA-WBC (”tumor-normal”) assay to detect somatic alterations
Sensitivity for mutation calling depends on ‘duplex’ collapsed coverage
Different sensitivities for different classes of alterations
Genotyping +++++
De novo mutations, indels ++++
MSI +++
Rearrangements +++
Copy number ++
Tumor mutation burden ○
+ -> sensitivity for that event type
○ -> cannot be calculated